Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy.

doi:10.1038/s41467-025-67738-w

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Article

Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy.

Nature communications - 18 Dec 2025

Koon Alex Chun, Yeung Ka Yee Winnie, Wu Yitao, Leong Lok I, Cheung John Tsun Po, Chen Zhefan Stephen, Peng Shaohong Isaac, Armstrong Noah S, Frank C Andrew, Magneron Paul, Gomes-Pereira Mário, Fung Joyce Man See, Bargiela Ariadna, Moreno Nerea, Poyatos-Garcia Javier, Vilchez Juan, Huguet-Lachon Aline, Brewer Cassandra Kussius, Zinter Max, Beck Erin S, Artero Rubén, Gourdon Genevieve, Budnik Vivian, Thomson Travis, McCabe Brian D, Chan Ho Yin Edwin

Abstract excerpt

Myotonic dystrophy type 1 is a multisystemic disorder that has been extensively studied for decades, yet our understanding of its neuropathological aspect remains rudimentary. Building on an established Drosophila model, we study the neuropathological features of the disease by expressing untranslated expanded CUG repeats at the Drosophila larval neuromuscular junction. In this model, we show that both pre- and...

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PMID: 41413387
DOI: 10.1038/s41467-025-67738-w
PMCID: PMC12847815

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NCAM1

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