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Article

A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas.

PloS one - 1 Jan 2015

Ling Chao, Wang Lin, Wang Zheng, Xu Luming, Sun Lifang, Yang Hui, Li Wei-Dong, Wang Kai

Abstract excerpt

Previous genetic studies on colorectal carcinomas (CRC) have identified multiple somatic mutations in four candidate pathways (TGF-β, Wnt, P53 and RTK-RAS pathways) on populations of European ancestry. However, it is under-studied whether other populations harbor different sets of hot-spot somati...

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Identifiers

PMID: 25617745
DOI: 10.1371/journal.pone.0116753
PMCID: PMC4305320

Genes

APC
PTEN
BRAF
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25617745-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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