Article
Patch formation of a viral channel forming protein within a lipid membrane--Vpu of HIV-1.
Molecular bioSystems - 1 Apr 2016
Lin Meng-Han, Chen Chin-Pei, Fischer Wolfgang B
Abstract excerpt
Ion channels and their viral companions are defined by their quaternary structure. The individual sub-units have to assemble into homo- or hetero-oligomers. Using Vpu of HIV-1, a putative viral channel forming protein (VCP), as a test case, the formation of a quaternary structure is monitored using coarse grained molecular dynamics (CGMD) simulations. Full length Vpu is generated by combining the helical...
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