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Article

Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers.

Protein science : a publication of the Protein Society - 1 Oct 2010

Lu Jun-Xia, Sharpe Simon, Ghirlando Rodolfo, Yau Wai-Ming, Tycko Robert

Abstract excerpt

HIV-1 Vpu is an 81-residue protein with a single N-terminal transmembrane (TM) helical segment that is involved in the release of new virions from host cell membranes. Vpu and its TM segment form ion channels in phospholipid bilayers, presumably by oligomerization of TM helices into a pore-like s...

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Identifiers

PMID: 20669237
DOI: 10.1002/pro.474
PMCID: PMC2998723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20669237-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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