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Article

Computational analysis of mutations in the transmembrane region of Vpu from HIV-1.

Biochimica et biophysica acta - 1 Oct 2005

Candler Andrew, Featherstone Matthew, Ali Rehan, Maloney Leslie, Watts Anthony, Fischer Wolfgang B

Abstract excerpt

Vpu is an 81 amino acid integral membrane protein encoded by HIV-1. Its alpha-helical transmembrane (TM) domain (residues approximately 6-28) enhances virion release by oligomerizing into bundles and forming ion-conducting channels across the plasma membrane. Its cytoplasmic domain (residues approximately 29-81) is also alpha-helical and binds to the transmembrane protein CD4, inducing its degradation. Mutations...

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PMID: 16154109
DOI: 10.1016/j.bbamem.2005.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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