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Article

Asymmetric dynamics of ion channel forming proteins - Hepatitis C virus (HCV) p7 bundles.

Biochimica et biophysica acta - 1 Jul 2016

Kalita Monoj Mon, Fischer Wolfgang B

Abstract excerpt

Protein p7 of hepatitis C virus (HCV) is a short 63 amino acid membrane protein which homo-oligomerises in the lipid membrane to form ion and proton conducting bundles. Two different genotypes (GTs) of p7, 1a and 5a, are used to simulate hexameric bundles of the protein embedded in a fully hydrated lipid bilayer during 400 ns molecular dynamics (MD) simulations. Whilst the bundle of GT 1a is based on a fully...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27079148
DOI: 10.1016/j.bbamem.2016.04.004

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