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Article

Effect of flanking residues on the conformational sampling of the internal fusion peptide from Ebola virus.

Proteins - 1 Apr 2011

Jaskierny Adam J, Panahi Afra, Feig Michael

Abstract excerpt

Fusion peptides mediate viral and host-cell membrane fusion during viral entry. The monomeric form of the internal fusion peptide from Ebola virus was studied in membrane bilayer and water environments with computer simulations using replica exchange sampling and an implicit solvent description of the environment. Wild-type Ebola fusion peptide (EFP), the W8A mutant form, and an extended construct with flanking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21246633
DOI: 10.1002/prot.22947
PMCID: PMC3075865

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