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Article

Cannabinoid Control of Learning and Memory through HCN Channels.

Neuron - 2 Mar 2016

Maroso Mattia, Szabo Gergely G, Kim Hannah K, Alexander Allyson, Bui Anh D, Lee Sang-Hun, Lutz Beat, Soltesz Ivan

Abstract excerpt

The mechanisms underlying the effects of cannabinoids on cognitive processes are not understood. Here we show that cannabinoid type-1 receptors (CB1Rs) control hippocampal synaptic plasticity and spatial memory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the h-current (Ih), a key regulator of dendritic excitability. The CB1R-HCN pathway, involving c-Jun-N-terminal...

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Source

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Identifiers

PMID: 26898775
DOI: 10.1016/j.neuron.2016.01.023
PMCID: PMC4777634

Genes

HCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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