Article

Sub-chronic peripheral CB1R inhibition enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice

2023-11-21

Abstract excerpt

<h4>Background and Purpose</h4> The peripheral contribution to brain function and cognitive performance is far from understood. Cannabinoid type-1 receptor (CB1R) is classically pictured in the central nervous system to have such a role. We previously demonstrated a novel mechanism where the acute peripheral CB1R inhibition in mice prolongs memory persistence. Here, we take advance of the repeated exposure to the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 467c3a3b-dc46-500f-8171-5e85ad0a508f
DOI: 10.1101/2023.11.21.567995

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sub-chronic peripheral CB1R inhibition enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve miceDOI 10.1101/2023.11.21.567995Read

Electrophysiological Phenotypes of Hippocampal Synaptic and Network Functions in Cannabinoid Receptor 2 Knockout Mice.Semantic proximity Read

Single cannabidiol administration affects anxiety-, obsessive compulsive-, object memory-, and attention-like behaviors in mice in a sex and concentration dependent mannerSemantic proximity Read

Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid systemSemantic proximity Read

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.Semantic proximity Read

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male miceSemantic proximity Read

The CB <sub>1</sub> receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfallsSemantic proximity Read

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndromeSemantic proximity Read

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male miceSemantic proximity Read

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairmentSemantic proximity Read

Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged miceSemantic proximity Read

Prenatal Cannabidiol and THC Exposure Induce Sex-Specific Executive Dysfunction via Divergent Pathological Rewiring of the Adult Medial Prefrontal CortexSemantic proximity Read

Cognition Enhancement Strategies: Figure 1.Semantic proximity Read