Article

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons

2022-08-14

Abstract excerpt

<h4>Summary</h4> Endogenous cannabinoid signaling is vital for important brain functions and can be modified pharmacologically to treat pain, epilepsy, and posttraumatic stress disorder. Endocannabinoid mediated changes to excitability are predominantly attributed to 2-arachidonoylglycerol at synapses. Here we identify a pathway in the neocortex by which anandamide, the other major endocannabinoid, powerfully inh...

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Literature Corpus work: 04e9d20a-2b73-53f1-b55b-07e4cfbd6287
DOI: 10.1101/2022.08.12.503665

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Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neuronsDOI 10.1101/2022.08.12.503665Read

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