Article
Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia.
Neuropharmacology - 1 May 2018
Lu Jieping, Fan Sijia, Zou Guichang, Hou Yiwen, Pan Tao, Guo Weiwei, Yao Lei, Du Feng, Homanics Gregg E, Liu Dan, Zhang Li, Xiong Wei
Abstract excerpt
Some cannabinoids have been shown to suppress chronic pain by targeting glycine receptors (GlyRs). Although cannabinoid potentiation of α3 GlyRs is thought to contribute to cannabinoid-induced analgesia, the role of cannabinoid potentiation of α1 GlyRs in cannabinoid suppression of chronic pain remains unclear. Here we report that dehydroxylcannabidiol (DH-CBD), a nonpsychoactive cannabinoid, significantly...
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