Article
Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus.
The European journal of neuroscience - 1 Jul 2003
Ohno-Shosaku Takako, Matsui Minoru, Fukudome Yuko, Shosaku Jumpei, Tsubokawa Hiroshi, Taketo Makoto M, Manabe Toshiya, Kano Masanobu
Abstract excerpt
The cholinergic system is crucial for higher brain functions including learning and memory. These functions are mediated primarily by muscarinic acetylcholine receptors (mAChRs) that consist of five subtypes (M(1)-M(5)). A recent study suggested a novel role of acetylcholine as a potent enhancer of endocannabinoid signalling that acts retrogradely from postsynaptic to presynaptic neurons. In the present study, we...
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