Article
HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.
Molecular psychiatry - 1 Nov 2015
Omrani A, van der Vaart T, Mientjes E, van Woerden G M, Hojjati M R, Li K W, Gutmann D H, Levelt C N, Smit A B, Silva A J, Kushner S A, Elgersma Y
Abstract excerpt
Cognitive impairments are a major clinical feature of the common neurogenetic disease neurofibromatosis type 1 (NF1). Previous studies have demonstrated that increased neuronal inhibition underlies the learning deficits in NF1, however, the molecular mechanism underlying this cell-type specificity has remained unknown. Here, we identify an interneuron-specific attenuation of hyperpolarization-activated cyclic...
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