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Article

Distinct and overlapping genomic profiles and antiviral effects of Interferon‐λ and ‐α on HCV‐infected and noninfected hepatoma cells

27 May 2012

Abstract excerpt

Recently, several SNPs in the region of the IL28B (IFN-λ) gene have been associated with spontaneous clearance of hepatitis C virus (HCV) and enhanced cure rates for IFN-alfa-based therapies, suggesting a potential correlation between IFN-λ and the ability to clear HCV. To understand the mechanism of IFN-λ's as compared to IFN-α's antiviral activity, we performed a comprehensive analysis of their anti-HCV...

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PMID: 23121362
DOI: 10.1111/j.1365-2893.2012.01610.x

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