Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of interferon lambda 3 gene polymorphism on natural course and treatment of hepatitis C.

Clinical & developmental immunology - 1 Jan 2012

Bellanti F, Vendemiale G, Altomare E, Serviddio G

Abstract excerpt

Host genetic factors may predict the outcome and treatment response in hepatitis C virus (HCV) infection. Very recently, three landmark genome-wide association studies identified single nucleotide polymorphisms near the interleukin 28B (IL28B) region which were more frequent in responders to treatment. IL28B encodes interferon (IFN)λ3, a type III IFN involved in host antiviral immunity. Favourable variants of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Hepacivirus
Share to Hepatitis C

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferons

Share to Interleukins

Share to Polymorphism, Single Nucleotide

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 22966241
DOI: 10.1155/2012/849373
PMCID: PMC3433716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of interferon lambda 3 gene polymorphism on natural course and treatment of hepatitis C.PMID 22966241Read ↗

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.Semantic proximity Read ↗

Systematic review with meta-analysis: do interferon lambda 3 polymorphisms predict the outcome of interferon-therapy in hepatitis B infection?Semantic proximity Read ↗

IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.Semantic proximity Read ↗

Genetics of IL28B and HCV--response to infection and treatment.Semantic proximity Read ↗

IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.Semantic proximity Read ↗

The role of genetic markers in hepatitis C virus therapy: a major step for individualized care.Semantic proximity Read ↗

IL28B in hepatitis C virus infection: translating pharmacogenomics into clinical practice.Semantic proximity Read ↗

Role of IL28B for chronic hepatitis C treatment toward personalized medicine.Semantic proximity Read ↗

Host genomics and HCV treatment response.Semantic proximity Read ↗

The Role of Interferon-&#x03BB; Locus Polymorphisms in Hepatitis C and Other Infectious DiseasesSemantic proximity Read ↗

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.Semantic proximity Read ↗

IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: the future of personalized HCV therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.