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Article

Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis.

Scientific reports - 19 Feb 2016

Shen Keyue, Luk Samantha, Elman Jessica, Murray Ryan, Mukundan Shilpaa, Parekkadan Biju

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are a major cancer-promoting component in the tumor microenvironment (TME). The dynamic role of human CAFs in cancer progression has been ill-defined because human CAFs lack a unique marker needed for a cell-specific, promoter-driven knockout model. Here, we developed an engineered human CAF cell line with an inducible suicide gene to enable selective in vivo elimination of...

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Source

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Identifiers

PMID: 26893143
DOI: 10.1038/srep21239
PMCID: PMC4759812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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