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Article

Dynamic Immune Cell Composition, Phenotypes, and Signaling in an Engineered Metastatic Niche.

Biotechnology and bioengineering - 1 Apr 2026

Pereles Rebecca S, Roy Jyotirmoy, Brooks Michael D, Wicha Max S, Jeruss Jacqueline S, Shea Lonnie D, Orbach Sophia M

Abstract excerpt

In breast cancer patients, metastasis is the stage of disease where prognosis significantly worsens. However, the timing at which metastasis initiates and the location of metastatic lesions in an organ are stochastic, limiting the timely identification of disease and the administration of treatments. Herein, we employ a synthetic metastatic niche comprised of a microporous scaffold to investigate the dynamic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41518488
DOI: 10.1002/bit.70140
PMCID: PMC13003427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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