Article
Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.
Sleep - 1 Apr 2016
Chen Yung-Che, Chen Ting-Wen, Su Mao-Chang, Chen Chung-Jen, Chen Kuang-Den, Liou Chia-Wei, Tang Petrus, Wang Ting-Ya, Chang Jen-Chieh, Wang Chin-Chou, Lin Hsin-Ching, Chin Chien-Hung, Huang Kuo-Tung, Lin Meng-Chih, Hsiao Chang-Chun
Abstract excerpt
STUDY OBJECTIVES: We hypothesized that DNA methylation patterns may contribute to disease severity or the development of hypertension and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA). METHODS: Illumina's (San Diego, CA, USA) DNA methylation 27-K assay was used to identify differentially methylated loci (DML). DNA methylation levels were validated by pyrosequencing. A discovery...
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