Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant DNA methylation of the toll-like receptors 2 and 6 genes in patients with obstructive sleep apnea.

PloS one - 1 Jan 2020

Huang Kuo-Tung, Chen Yung-Che, Tseng Chia-Cheng, Chang Huang-Chih, Su Mao-Chang, Wang Ting-Ya, Lin Yong-Yong, Zheng Yi-Xin, Chang Jen-Chieh, Chin Chien-Hung, Hsiao Chang-Chun, Lin Meng-Chih

Abstract excerpt

Obstructive sleep apnea (OSA) is a syndrome leading to chronic intermittent hypoxia, and the up-regulation of toll-like receptors (TLR) 2 and 6 on peripheral blood cells has been reported. We hypothesized that DNA methylation in TLR2 and TLR6 genes may play a role in the development of OSA and its excessive daytime sleepiness (EDS) phenotype. DNA methylation over 28 cytosine-phosphate-guanine (CpG) sites of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polysomnography

Share to Sleep Apnea, Obstructive

Share to Taiwan

Share to Toll-Like Receptor 2

Share to Toll-Like Receptor 6

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 32069296
DOI: 10.1371/journal.pone.0228958
PMCID: PMC7028278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant DNA methylation of the toll-like receptors 2 and 6 genes in patients with obstructive sleep apnea.PMID 32069296Read ↗

Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.Semantic proximity Read ↗

Hypomethylation of the Toll-like receptor-2 gene increases the risk of essential hypertension.Semantic proximity Read ↗

Epigenetic alterations in obstructive sleep Apnea: a pooled analysis of DNA methylation profiles in humans and animal modelsSemantic proximity Read ↗

Epigenetic changes by DNA methylation in chronic and intermittent hypoxiaSemantic proximity Read ↗

The role inflammatory response genes in obstructive sleep apnea syndrome: a review.Semantic proximity Read ↗

ALKBH5 Regulates m6A Methylation-modified Pre-miR-21 to Promote Lung Injury in Obstructive Sleep Apnea Rat ModelSemantic proximity Read ↗

The theranostic value of acetylation gene signatures in obstructive sleep apnea derived by machine learningSemantic proximity Read ↗

Roles of interleukin (IL)-6 gene polymorphisms, serum IL-6 levels, and treatment in obstructive sleep apnea: a meta-analysis.Semantic proximity Read ↗

HLA-DRB1 allele frequency and immunological response in obstructive sleep apnea syndrome in Turkish population.Semantic proximity Read ↗

Redistribution of Monocyte Subsets in Obstructive Sleep Apnea Syndrome Patients Leads to an Imbalanced PD-1/PD-L1 Cross-Talk with CD4/CD8 T CellsSemantic proximity Read ↗

Epigenetic in Obstructive Sleep Apnea: miR-145-5p targets DNMT3A and regulates DNA methylation homeostasis in upper airway muscleSemantic proximity Read ↗

Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.