Article
Genome-wide gene expression array identifies novel genes related to disease severity and excessive daytime sleepiness in patients with obstructive sleep apnea.
PloS one - 1 Jan 2017
Chen Yung-Che, Chen Kuang-Den, Su Mao-Chang, Chin Chien-Hung, Chen Chung-Jen, Liou Chia-Wei, Chen Ting-Wen, Chang Ya-Chun, Huang Kuo-Tung, Wang Chin-Chou, Wang Ting-Ya, Chang Jen-Chieh, Lin Yong-Yong, Zheng Yi-Xin, Lin Meng-Chih, Hsiao Chang-Chun
Abstract excerpt
We aimed to identify novel molecular associations between chronic intermittent hypoxia with re-oxygenation and adverse consequences in obstructive sleep apnea (OSA). We analyzed gene expression profiles of peripheral blood mononuclear cells from 48 patients with sleep-disordered breathing stratified into four groups: primary snoring (PS), moderate to severe OSA (MSO), very severe OSA (VSO), and very severe OSA...
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