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Article

Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis

5 Jul 2012

Abstract excerpt

INTRODUCTION: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising death ligand who has received significant attention due to its specific anti-cancer activity. Recently, a number of clinical trials involving either recombinant soluble TRAIL or agonistic death receptor (DR) antibodies have even been initiated. One major caveat in TRAIL-based anti-cancer therapies is that a considerable...

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PMID: 22762543
DOI: 10.1517/14728222.2012.703655

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