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Article

Reclassification of genetic-based risk predictions as GWAS data accumulate.

Genome medicine - 17 Feb 2016

Krier Joel, Barfield Richard, Green Robert C, Kraft Peter

Abstract excerpt

BACKGROUND: Disease risk assessments based on common genetic variation have gained widespread attention and use in recent years. The clinical utility of genetic risk profiles depends on the number and effect size of identified loci, and how stable the predicted risks are as additional loci are discovered. Changes in risk classification for individuals over time would undermine the validity of common genetic...

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Identifiers

PMID: 26884246
DOI: 10.1186/s13073-016-0272-5
PMCID: PMC4756503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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