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Article

Prospective Study of Cancer Genetic Variants: Variation in Rate of Reclassification by Ancestry.

Journal of the National Cancer Institute - 1 Oct 2018

Slavin Thomas P, Van Tongeren Lily R, Behrendt Carolyn E, Solomon Ilana, Rybak Christina, Nehoray Bita, Kuzmich Lili, Niell-Swiller Mariana, Blazer Kathleen R, Tao Shu, Yang Kai, Culver Julie O, Sand Sharon, Castillo Danielle, Herzog Josef, Gray Stacy W, Weitzel Jeffrey N

Abstract excerpt

Background: In germline genetic testing, variants from understudied ancestries have been disproportionately classified as being of uncertain significance. We hypothesized that the rate of variant reclassification likewise differs by ancestry. Methods: Nonbenign variants in actionable genes were collected from consenting subjects undergoing genetic testing at two Southern California sites from September 1996...

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Source

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Identifiers

PMID: 29618041
DOI: 10.1093/jnci/djy027
PMCID: PMC6249694

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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