Genetic analyses of eight complex diseases using predicted continuous representations of disease.

Abstract excerpt

We evaluated whether predicted continuous disease representations could enhance genetic discovery beyond case-control genome-wide association study (GWAS) phenotypes across eight complex diseases in up to 485,448 UK Biobank participants. Predicted phenotypes had high genetic correlations with case-control phenotypes (median rg = 0.66) but identified more independent associations (median 306 versus 125). While...

Topics

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• Case-Control Studies
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Multifactorial Inheritance
• Phenotype