Article
Melanoma genome sequencing reveals frequent PREX2 mutations.
Nature - 9 May 2012
Berger Michael F, Hodis Eran, Heffernan Timothy P, Deribe Yonathan Lissanu, Lawrence Michael S, Protopopov Alexei, Ivanova Elena, Watson Ian R, Nickerson Elizabeth, Ghosh Papia, Zhang Hailei, Zeid Rhamy, Ren Xiaojia, Cibulskis Kristian, Sivachenko Andrey Y, Wagle Nikhil, Sucker Antje, Sougnez Carrie, Onofrio Robert, Ambrogio Lauren, Auclair Daniel, Fennell Timothy, Carter Scott L, Drier Yotam, Stojanov Petar, Singer Meredith A, Voet Douglas, Jing Rui, Saksena Gordon, Barretina Jordi, Ramos Alex H, Pugh Trevor J, Stransky Nicolas, Parkin Melissa, Winckler Wendy, Mahan Scott, Ardlie Kristin, Baldwin Jennifer, Wargo Jennifer, Schadendorf Dirk, Meyerson Matthew, Gabriel Stacey B, Golub Todd R, Wagner Stephan N, Lander Eric S, Getz Gad, Chin Lynda, Garraway Levi A
Abstract excerpt
Melanoma is notable for its metastatic propensity, lethality in the advanced setting and association with ultraviolet exposure early in life. To obtain a comprehensive genomic view of melanoma in humans, we sequenced the genomes of 25 metastatic melanomas and matched germline DNA. A wide range of point mutation rates was observed: lowest in melanomas whose primaries arose on non-ultraviolet-exposed hairless skin...
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