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Article

P-Rex1 and P-Rex2 RacGEFs and cancer.

Biochemical Society transactions - 15 Aug 2017

Srijakotre Nuthasuda, Man Joey, Ooms Lisa M, Lucato Christina M, Ellisdon Andrew M, Mitchell Christina A

Abstract excerpt

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger (P-Rex) proteins are RacGEFs that are synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and Gβγ subunits of G-protein-coupled receptors. P-Rex1 and P-Rex2 share similar amino acid sequence homology, domain structure, and catalytic function. Recent evidence suggests that both P-Rex proteins may play oncogenic roles in human...

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Identifiers

PMID: 28710285
DOI: 10.1042/BST20160269

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