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Article

Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas.

Cancer research - 1 May 2013

Burnett-Hartman Andrea N, Newcomb Polly A, Potter John D, Passarelli Michael N, Phipps Amanda I, Wurscher Michelle A, Grady William M, Zhu Lee-Ching, Upton Melissa P, Makar Karen W

Abstract excerpt

A subset of aggressive colorectal cancers exhibit BRAF mutation, MLH1 methylation, and a CpG island methylator phenotype (CIMP), but precursors are poorly established. In this study, we determined the status of these markers in colorectal polyps and evaluated associated risk factors. The study included 771 polyp cases and 1,027 controls who were ages 24 to 80 years, part of a group health program, received a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23539450
DOI: 10.1158/0008-5472.CAN-12-3462
PMCID: PMC3815695

Genes

BRAF
MLH1
IGF2
NEUROG1
RUNX3
SOCS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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