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Rapid CD4+ T-cell decline is associated with coreceptor switch among MSM primarily infected with HIV-1 CRF01_AE in Northeast China.

AIDS (London, England) - 27 Jan 2019

Cui Hualu, Geng Wenqing, Sun Hong, Han Xiaoxu, An Minghui, Jiang Yongjun, Zhang Zining, Chen Zhiwei, Xu Junjie, Hu Qinghai, Zhao Bin, Zhou Bennan, Shang Hong

Abstract excerpt

OBJECTIVE: CRF01_AE is the most prevalent HIV-1 subtype among MSM in China. However, the characteristics and underlying mechanism of the accelerated CD4 T-cell decline in CRF01_AE-infected MSM remain incompletely understood. DESIGN: A long-term prospective follow-up study was conducted with 1388 MSM at risk of HIV-1 infection in Northeast China. MSM with primary HIV-1 CRF01_AE infection were identified and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30102662
DOI: 10.1097/QAD.0000000000001981

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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