Comprehensive epidemiological and genotype-phenotype analyses in a large European sample with idiopathic achalasia.

doi:10.1097/MEG.0000000000000602

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Article

Comprehensive epidemiological and genotype-phenotype analyses in a large European sample with idiopathic achalasia.

European journal of gastroenterology & hepatology - 1 Jun 2016

Becker Jessica, Niebisch Stefan, Ricchiuto Arcangelo, Schaich Eva J, Lehmann Gavin, Waltgenbach Tobias, Schafft Annette, Hess Timo, Lenze Frank, Venerito Marino, Hüneburg Robert, Lingohr Philipp, Matthaei Hanno, Seewald Stefan, Scheuermann Uwe, Kreuser Nicole, Veits Lothar, Wouters Mira M, Gockel Henning R, Lang Hauke, Vieth Michael, Müller Michaela, Eckardt Alexander J, von Rahden Burkhard H A, Knapp Michael, Boeckxstaens Guy E, Fimmers Rolf, Nöthen Markus M, Schulz Henning G, Gockel Ines, Schumacher Johannes

Abstract excerpt

BACKGROUND AND AIM: Although an eight-residue insertion in HLA-DQβ1 has been recently identified as a genetic risk factor for idiopathic achalasia, other risk factors are still unknown. In the present study, we carried out an epidemiological survey and a genotype-phenotype (G×P) analysis to gain further insights into the etiology of achalasia. METHODS: We obtained medical data from 696 achalasia patients and 410...

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PMID: 26882171
DOI: 10.1097/MEG.0000000000000602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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