Article
Presence of a protective allele for achalasia on the central region of the major histocompatibility complex.
Tissue antigens - 1 Aug 2000
de la Concha E G, Fernandez-Arquero M, Conejero L, Lazaro F, Mendoza J L, Sevilla M C, Diaz-Rubio M, Ruiz de Leon A
Abstract excerpt
Idiopathic achalasia is a motility disorder of the esophagus whose etiology is unknown. An association between HLA genes and susceptibility to achalasia which suggests a possible immunogenetic mechanism has been reported recently. This study was designed to examine the HLA class II association in a large group of achalasia patients further and to investigate the distribution of TNFa and TNFb microsatellites in...
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