An original Eurasian haplotype, HLA-DRB1*14:54-DQB1*05:03, influences the susceptibility to idiopathic achalasia.

doi:10.1371/journal.pone.0201676

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Article

An original Eurasian haplotype, HLA-DRB114:54-DQB105:03, influences the susceptibility to idiopathic achalasia.

PloS one - 1 Jan 2018

Furuzawa-Carballeda Janette, Zuñiga Joaquín, Hernández-Zaragoza Diana I, Barquera Rodrigo, Marques-García Eduardo, Jiménez-Alvarez Luis, Cruz-Lagunas Alfredo, Ramírez Gustavo, Regino Nora E, Espinosa-Soto Ramón, Yunis Edmond J, Romero-Hernández Fernanda, Azamar-Llamas Daniel, Coss-Adame Enrique, Valdovinos Miguel A, Torres-Landa Samuel, Palacios-Ramírez Axel, Breña Blanca, Alejandro-Medrano Edgar, Hernández-Ávila Axel, Granados Julio, Torres-Villalobos Gonzalo

Abstract excerpt

Idiopathic achalasia is a relatively infrequent esophageal motor disorder for which major histocompatibility complex (MHC) genes are well-identified risk factors. However, no information about HLA-achalasia susceptibility in Mexicans has previously been reported. We studied a group of 91 patients diagnosed with achalasia and 234 healthy controls with Mexican admixed ancestry. HLA alleles and conserved extended...

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PMID: 30092016
DOI: 10.1371/journal.pone.0201676
PMCID: PMC6084941

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