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Article

Gender-specific association of the PTPN22 C1858T polymorphism with achalasia.

Human immunology - 1 Oct 2007

Santiago Jose Luis, Martínez Alfonso, Benito M Soledad, Ruiz de León Antonio, Mendoza Juan Luis, Fernández-Arquero Miguel, Figueredo M Angeles, de la Concha Emilio G, Urcelay Elena

Abstract excerpt

The protein tyrosine phosphatase N22 (PTPN22) gene encodes a lymphoid-specific phosphatase (LYP), a downregulator of T-cell activation. Because a functional PTPN22 polymorphism, C1858T, has been found to be associated with different autoimmune diseases, we aimed to elucidate the role of this variant in predisposition to achalasia. We performed a case-control study with 231 nonrelated Spanish patients of white...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Esophageal Achalasia

Share to Polymorphism, Genetic

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Identifiers

PMID: 17961776
DOI: 10.1016/j.humimm.2007.07.005

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Gender-specific association of the PTPN22 C1858T polymorphism with achalasia.PMID 17961776Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

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