Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia.

doi:10.1136/gutjnl-2013-304848

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Article

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia.

Gut - 1 Sept 2014

Wouters Mira M, Lambrechts Diether, Becker Jessica, Cleynen Isabelle, Tack Jan, Vigo Ana G, Ruiz de León Antonio, Urcelay Elena, Pérez de la Serna Julio, Rohof Wout, Annese Vito, Latiano Anna, Palmieri Orazio, Mattheisen Manuel, Mueller Michaela, Lang Hauke, Fumagalli Uberto, Laghi Luigi, Zaninotto Giovanni, Cuomo Rosario, Sarnelli Giovanni, Nöthen Markus M, Vermeire Séverine, Knapp Michael, Gockel Ines, Schumacher Johannes, Boeckxstaens Guy E

Abstract excerpt

BACKGROUND: Idiopathic achalasia is a rare motor disorder of the oesophagus characterised by neuronal loss at the lower oesophageal sphincter. Achalasia is generally accepted as a multifactorial disorder with various genetic and environmental factors being risk-associated. Since genetic factors predisposing to achalasia have been poorly documented, we assessed whether single nucleotide polymorphisms (SNPs) in...

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PMID: 24259423
DOI: 10.1136/gutjnl-2013-304848

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