Article
A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.
Journal of obesity - 1 Jan 2015
Hasstedt Sandra J, Xin Yuanpei, Mao Rong, Lewis Tracey, Adams Ted D, Hunt Steven C
Abstract excerpt
BACKGROUND/OBJECTIVES: To identify copy number variants (CNVs) which are associated with body mass index (BMI). SUBJECTS/METHODS: CNVs were identified using array comparative genomic hybridization (aCGH) on members of pedigrees ascertained through severely obese (BMI ≥ 35 kg/m(2)) sib pairs (86 pedigrees) and thin (BMI ≤ 23 kg/m(2)) probands (3 pedigrees). Association was inferred through pleiotropy of BMI with...
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