Article
Copy number variation on chromosome 10q26.3 for obesity identified by a genome-wide study.
The Journal of clinical endocrinology and metabolism - 1 Jan 2013
Yang Tie-Lin, Guo Yan, Shen Hui, Li Jian, Glessner Joseph T, Qiu Chuan, Deng Fei-Yan, Tian Qing, Yu Ping, Liu Yao-Zhong, Liu Yong-Jun, Hakonarson Hakon, Grant Struan F A, Deng Hong-Wen
Abstract excerpt
BACKGROUND: Obesity is a highly heritable disease defined by high body mass index (BMI). However, a large proportion of the heritability of obesity remains unexplained. Copy number variations (CNVs) might contribute to the missing heritability of obesity. METHODS: We conducted genome-wide CNV analyses on obesity phenotypes, including BMI and body fat mass in a discovery sample of 2215 unrelated white subjects....
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