Article

Inducible activation of PKA in osteoblasts causes a profound high bone turnover phenotype similar to human diseases

2026-03-13

Abstract excerpt

Protein kinase A (PKA) is involved in bone biology and is a key mediator of parathyroid hormone signaling in the osteoblast. However, the consequences of sustained PKA activation in bone are unclear. In this study, we inducibly activated PKA in osteoblasts by deleting its major regulatory subunit, Prkar1a , using a Col1α1-driven Cre system. Prkar1a ob-/- mice demonstrated rapid and profound bone pathologies in...

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Literature Corpus work: b8accfd2-1dab-5075-8fdf-dcb38707bcb4
DOI: 10.64898/2026.03.11.709826

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