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Article

Trachelogenin, a novel inhibitor of hepatitis C virus entry through CD81.

The Journal of general virology - 1 May 2016

Qian Xi-Jing, Jin Yong-Sheng, Chen Hai-Sheng, Xu Qing-Qiang, Ren Hao, Zhu Shi-Ying, Tang Hai-Lin, Wang Yan, Zhao Ping, Qi Zhong-Tian, Zhu Yong-Zhe

Abstract excerpt

Although much progress has been made in antiviral agents against hepatitis C virus (HCV) in recent years, novel HCV inhibitors with improved efficacy, optimized treatment duration and more affordable prices are still urgently needed. Here, we report the identification of a natural plant-derived lignan, trachelogenin (TGN), as a potent entry inhibitor of HCV without genotype specificity, and with low cytotoxicity....

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PMID: 26879209
DOI: 10.1099/jgv.0.000432

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