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Article

A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.

Gastroenterology - 1 Jul 2012

Haid Sibylle, Novodomská Alexandra, Gentzsch Juliane, Grethe Christina, Geuenich Silvia, Bankwitz Dorothea, Chhatwal Patrick, Jannack Beate, Hennebelle Thierry, Bailleul Francois, Keppler Oliver T, Poenisch Marion, Bartenschlager Ralf, Hernandez Céline, Lemasson Matthieu, Rosenberg Arielle R, Wong-Staal Flossie, Davioud-Charvet Elisabeth, Pietschmann Thomas

Abstract excerpt

BACKGROUND & AIMS: Interferon-based therapies for hepatitis C virus (HCV) infection are limited by side effects and incomplete response rates, particularly among transplant recipients. We screened a library of plant-derived small molecules to identify HCV inhibitors with novel mechanisms. METHODS...

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Source

Identifiers

PMID: 22465429
DOI: 10.1053/j.gastro.2012.03.036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22465429-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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