Article
Structure-activity relationships of fluorene compounds inhibiting HCV variants.
Antiviral research - 1 Feb 2020
Kim Hee Sun, You Youngsu, Mun Jaegon, Gadhe Changdev G, Moon Heejo, Lee Jae Seung, Pae Ae Nim, Kohara Michinori, Keum Gyochang, Kim Byeong Moon, Jang Sung Key
Abstract excerpt
Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths annually. Effective direct-acting antiviral agents (DAAs) have been developed and are currently used for HCV treatment targeting the following three proteins:...
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