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Article

Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

The Journal of infectious diseases - 5 May 2018

Rolt Adam, Le Derek, Hu Zongyi, Wang Amy Q, Shah Pranav, Singleton Marc, Hughes Emma, Dulcey Andrés E, He Shanshan, Imamura Michio, Uchida Takuro, Chayama Kazuaki, Xu Xin, Marugan Juan J, Liang T Jake

Abstract excerpt

Hepatitis C virus (HCV) is a small, single-stranded, positive-sense RNA virus that infects more than an estimated 70 million people worldwide. Untreated, persistent HCV infection often results in chronic hepatitis, cirrhosis, or liver failure, with progression to hepatocellular carcinoma. Current anti-HCV regimens comprising direct acting antivirals (DAAs) can provide curative treatment; however, due to high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29373739
DOI: 10.1093/infdis/jiy039
PMCID: PMC5946821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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