Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

Abstract excerpt

LGI1 in humans is responsible for a predisposition to autosomal dominant partial epilepsy with auditory features (ADPEAF). However, mechanisms of how LGI1 mutations cause epilepsy remain unclear. We have used a mouse chromosome engineering strategy to create a null mutation for the gene ortholog encoding LGI1. The Lgi1 null mutant mice show no gross overall developmental abnormalities from routine...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoimmune Neurological Disorders and Treatments
• Share to Genetics and Neurodevelopmental Disorders
• Share to Neuroscience and Neuropharmacology Research