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Article

Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy.

Nature medicine - 1 Oct 2009

Zhou Yu-Dong, Lee Sanghoon, Jin Zhe, Wright Moriah, Smith Stephen E P, Anderson Matthew P

Abstract excerpt

A subset of central glutamatergic synapses are coordinately pruned and matured by unresolved mechanisms during postnatal development. We report that the human epilepsy gene LGI1, encoding leucine-rich, glioma-inactivated protein-1 and mutated in autosomal dominant lateral temporal lobe epilepsy (ADLTE), mediates this process in hippocampus. We created transgenic mice either expressing a truncated mutant LGI1...

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Share to Epilepsy, Temporal Lobe
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Intracellular Signaling Peptides and Proteins

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Share to Receptors, GABA-B

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Source

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Identifiers

PMID: 19701204
DOI: 10.1038/nm.2019
PMCID: PMC2759408

Genes

LGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy.PMID 19701204Read ↗

LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal developmentSemantic proximity Read ↗

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsySemantic proximity Read ↗

Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizuresSemantic proximity Read ↗

LGI1: from zebrafish to human epilepsy.Semantic proximity Read ↗

The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.Semantic proximity Read ↗

Autosomal dominant lateral temporal epilepsy in a family exhibiting a rare heterozygous mutation and deletion in the leucine-rich glioma inactivated 1 gene.Semantic proximity Read ↗

Role of LGI1 protein in synaptic transmission: From physiology to pathologySemantic proximity Read ↗

Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitabilitySemantic proximity Read ↗

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.Semantic proximity Read ↗

Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.Semantic proximity Read ↗

Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons.Semantic proximity Read ↗

Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features.Semantic proximity Read ↗

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