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Article

Pancreatic cancer induced by in vivo electroporation-enhanced sleeping beauty transposon gene delivery system in mouse.

Pancreas - 1 May 2014

Park June-Shine, Lim Kyung-Min, Park Sung Goo, Jung Sun Young, Choi Hyun-Ji, Lee Do Hee, Kim Woo-Jin, Hong Seung-Mo, Yu Eun-Sil, Son Woo-Chan

Abstract excerpt

OBJECTIVE: The aim of this study was to establish a pancreatic tumor model of mouse using the electroporation-enhanced Sleeping Beauty (SB) transposon system. METHODS: The SB transposon system was used in conjunction with electroporation to deliver oncogenes, c-Myc and HRAS, and shRNA against p53 into the mouse pancreas to induce tumors. Oncogenes (c-Myc and HRAS) and shRNA against p53 gene were directly injected...

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Share to Electroporation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, myc

Share to Neoplasms, Experimental

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Share to Positron-Emission Tomography

Share to RNA, Small Interfering

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Source

Identifiers

PMID: 24713671
DOI: 10.1097/MPA.0000000000000102

Genes

HRAS

Provenance

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