Article
Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2005
Schwab Sibylle G, Franke Petra E, Hoefgen Barbara, Guttenthaler Vera, Lichtermann Dirk, Trixler Matyas, Knapp Michael, Maier Wolfgang, Wildenauer Dieter B
Abstract excerpt
The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one...
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