Article
MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1.
Cell reports - 23 Feb 2016
Guven-Ozkan Tugba, Busto Germain U, Schutte Soleil S, Cervantes-Sandoval Isaac, O'Dowd Diane K, Davis Ronald L
Abstract excerpt
MicroRNAs have been associated with many different biological functions, but little is known about their roles in conditioned behavior. We demonstrate that Drosophila miR-980 is a memory suppressor gene functioning in multiple regions of the adult brain. Memory acquisition and stability were both increased by miR-980 inhibition. Whole cell recordings and functional imaging experiments indicated that miR-980...
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