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Article

FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Sudhakaran Indulekha P, Hillebrand Jens, Dervan Adrian, Das Sudeshna, Holohan Eimear E, Hülsmeier Jörn, Sarov Mihail, Parker Roy, VijayRaghavan K, Ramaswami Mani

Abstract excerpt

Fragile X mental retardation protein (FMRP) and Ataxin-2 (Atx2) are triplet expansion disease- and stress granule-associated proteins implicated in neuronal translational control and microRNA function. We show that Drosophila FMRP (dFMR1) is required for long-term olfactory habituation (LTH), a phenomenon dependent on Atx2-dependent potentiation of inhibitory transmission from local interneurons (LNs) to...

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Identifiers

PMID: 24344294
DOI: 10.1073/pnas.1309543111
PMCID: PMC3890871

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