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Article

Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques.

Journal of virology - 1 Apr 2013

Xu Yin, Weatherall Chris, Bailey Michelle, Alcantara Sheilajen, De Rose Robert, Estaquier Jerome, Wilson Kim, Suzuki Kazuo, Corbeil Jacques, Cooper David A, Kent Stephen J, Kelleher Anthony D, Zaunders John

Abstract excerpt

T follicular helper (Tfh) cells are a specialized subset of memory CD4(+) T cells that are found exclusively within the germinal centers of secondary lymphoid tissues and are important for adaptive antibody responses and B cell memory. Tfh cells do not express CCR5, the primary entry coreceptor for both human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), and therefore, we...

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Topics

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Share to Lymphoid Tissue
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Real-Time Polymerase Chain Reaction

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to Statistics, Nonparametric

Share to T-Lymphocytes, Helper-Inducer

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Source

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Identifiers

PMID: 23325697
DOI: 10.1128/JVI.02497-12
PMCID: PMC3624224

Genes

CCR5
CXCR5
CXCR6
GPR15
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques.PMID 23325697Read ↗

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