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Article

Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene.

American journal of physiology. Heart and circulatory physiology - 15 Apr 2016

Ferrario Carlos M, VonCannon Jessica, Jiao Yan, Ahmad Sarfaraz, Bader Michael, Dell'Italia Louis J, Groban Leanne, Varagic Jasmina

Abstract excerpt

Angiotensin-(1-12) [ANG-(1-12)] is processed into ANG II by chymase in rodent and human heart tissue. Differences in the amino acid sequence of rat and human ANG-(1-12) render the human angiotensinogen (hAGT) protein refractory to cleavage by renin. We used transgenic rats harboring the hAGT gene [TGR(hAGT)L1623] to assess the non-renin-dependent effects of increased hAGT expression on heart function and arterial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26873967
DOI: 10.1152/ajpheart.00833.2015
PMCID: PMC4867338

Genes

ANG
ACE
ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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