Article
Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Sept 2003
Koga Takafumi, Urata Hidenori, Inoue Yukiko, Hoshino Takafumi, Okamoto Takehiro, Matsunaga Akira, Suzuki Misao, Miyazaki Junichi, Ideishi Munehito, Arakawa Kikuo, Saku Keijiro
Abstract excerpt
A number of in vitro studies have suggested potential pathophysiological roles of human (h-) chymase. However, the lack of an appropriate animal model has left the in vivo roles of chymase unclear. To approach this problem, a transgenic mouse (TGM) model carrying the h-chymase gene was establishe...
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