Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes.

doi:10.18632/oncotarget.7263

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Article

Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes.

Oncotarget - 22 Mar 2016

Wang Xiuchao, Ren He, Zhao Tiansuo, Ma Weidong, Dong Jie, Zhang Shengjie, Xin Wen, Yang Shengyu, Jia Li, Hao Jihui

Abstract excerpt

Hypoxia-inducible factor-1 alpha (HIF-1α) is over-expressed in many cancers including pancreatic ductal adenocarcinoma (PDAC) and correlated with poor prognosis. We aim to determine the effect of germline genetic variants on the regulation of the homeostasis of the miRNA-gene regulatory loop in HIF1A gene and PDAC risk. HIF1A rs2057482 single nucleotide polymorphism (SNP) was genotyped in 410 PDAC cases and 490...

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PMID: 26872370
DOI: 10.18632/oncotarget.7263
PMCID: PMC4924673

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